Gerrit Jansen Selected Research

N(alpha)- (4- amino- 4- deoxypteroyl)- N(delta)- hemiphthaloyl- L- ornithine (PT 523)

4/2006	Coexistence of multiple mechanisms of PT523 resistance in human leukemia cells harboring 3 reduced folate carrier alleles: transcriptional silencing, inactivating mutations, and allele loss.
1/2002	Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.

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Gerrit Jansen Research Topics

Disease

29	Neoplasms (Cancer) 04/2022 - 05/2003
26	Rheumatoid Arthritis 01/2022 - 07/2004
23	Leukemia 01/2021 - 01/2002
13	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 03/2020 - 01/2002
11	Breast Neoplasms (Breast Cancer) 01/2019 - 02/2003
8	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2020 - 07/2011
7	Arthritis (Polyarthritis) 01/2022 - 03/2013
7	Hematologic Neoplasms (Hematological Malignancy) 01/2018 - 03/2013
7	Multiple Myeloma 12/2017 - 09/2008
6	Inflammation (Inflammations) 03/2019 - 11/2009
5	Heart Arrest (Cardiac Arrest) 01/2022 - 02/2012
5	Mesothelioma 01/2020 - 08/2003
4	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 11/2009
4	Carcinoma (Carcinomatosis) 05/2014 - 03/2003
4	Colonic Neoplasms (Colon Cancer) 12/2011 - 08/2003
3	Carcinogenesis 12/2020 - 08/2013
3	Lung Neoplasms (Lung Cancer) 04/2014 - 08/2013
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2012 - 08/2003
2	Fistula 10/2021 - 10/2021
2	Sepsis (Septicemia) 10/2021 - 01/2021
2	Lymphoma (Lymphomas) 01/2020 - 04/2016
2	Myeloid Leukemia (Leukemia, Myelocytic) 01/2020 - 02/2016
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2019 - 01/2015
2	Synovitis 03/2014 - 03/2013
2	Colorectal Neoplasms (Colorectal Cancer) 12/2011 - 06/2007
2	Hereditary Folate Malabsorption 08/2009 - 09/2008
2	T-Cell Leukemia (Leukemia, T Cell) 04/2009 - 07/2008
2	Hypersensitivity (Allergy) 02/2003 - 02/2003
1	Out-of-Hospital Cardiac Arrest 12/2021
1	COVID-19 12/2021
1	Hemorrhage 10/2021

Drug/Important Bio-Agent (IBA)

29	Folic Acid (Vitamin M)FDA LinkGeneric 01/2022 - 01/2002
29	Methotrexate (Mexate)FDA LinkGeneric 10/2021 - 01/2002
22	Proteins (Proteins, Gene)FDA Link 01/2020 - 02/2003
19	Pharmaceutical PreparationsIBA 12/2020 - 01/2002
18	Bortezomib (Velcade)FDA Link 01/2021 - 09/2008
16	Proteasome InhibitorsIBA 01/2021 - 09/2008
12	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2021 - 07/2010
12	multidrug resistance-associated protein 1IBA 01/2019 - 02/2003
10	Folic Acid AntagonistsIBA 01/2021 - 01/2002
6	folylpolyglutamate synthetaseIBA 01/2021 - 02/2003
6	EnzymesIBA 10/2019 - 02/2003
6	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2019 - 02/2003
5	Pemetrexed (MTA)FDA Link 01/2021 - 01/2002
5	Thymidylate SynthaseIBA 01/2019 - 01/2002
5	Messenger RNA (mRNA)IBA 11/2016 - 08/2003
4	poly(ethylene glycol)-folateIBA 01/2020 - 03/2013
3	NucleotidesIBA 04/2022 - 04/2009
3	Amino Acids FDA Link 04/2022 - 08/2009
3	Folate Receptor 2IBA 01/2022 - 01/2009
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2017
3	RNA Precursors (Precursor, mRNA)IBA 01/2021 - 05/2015
3	GlucocorticoidsIBA 03/2020 - 10/2007
3	Proton-Coupled Folate TransporterIBA 01/2020 - 09/2008
3	Biological ProductsIBA 10/2019 - 01/2015
3	LigandsIBA 01/2019 - 03/2013
3	Adenosine Triphosphate (ATP)IBA 01/2019 - 01/2007
3	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2019 - 06/2004
3	AminopeptidasesIBA 01/2018 - 04/2014
3	UbiquitinIBA 01/2018 - 08/2013
3	methylated bovine serum albumin (MBSA)IBA 01/2018 - 03/2014
3	carfilzomibIBA 01/2014 - 04/2012
3	Leucovorin (Folinic Acid)FDA Link 12/2011 - 02/2003
3	7-hydroxymethotrexateIBA 04/2009 - 12/2004
3	Reduced Folate Carrier ProteinIBA 04/2006 - 02/2004
2	Oxygen (Dioxygen)IBA 04/2022 - 12/2021
2	CarbonIBA 01/2021 - 03/2019
2	RNA Splicing FactorsIBA 12/2020 - 05/2015
2	Dexamethasone (Maxidex)FDA LinkGeneric 01/2020 - 12/2013
2	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2020 - 01/2020
2	AntibodiesIBA 01/2018 - 01/2015
2	DNA (Deoxyribonucleic Acid)IBA 11/2016 - 02/2004
2	ProdrugsIBA 02/2016 - 04/2014
2	Rituximab (Mabthera)FDA Link 03/2015 - 01/2013
2	Antirheumatic Agents (DMARD)IBA 01/2015 - 04/2012
2	CytokinesIBA 01/2015 - 07/2011
2	(R)- (11C)1- (2- chlorophenyl)- N- methyl- N- (1- methylpropyl)- 3- isoquinolinecarboxamideIBA 01/2015 - 03/2013
2	PR-957IBA 01/2014 - 12/2013
2	Ligases (Synthetase)IBA 08/2013 - 04/2009
2	Fluorouracil (Carac)FDA LinkGeneric 12/2011 - 06/2007
2	Mitoxantrone (Novantrone)FDA LinkGeneric 01/2007 - 06/2004
2	N(alpha)- (4- amino- 4- deoxypteroyl)- N(delta)- hemiphthaloyl- L- ornithine (PT 523)IBA 04/2006 - 01/2002
1	NAD (NADH)IBA 04/2022
1	Bicarbonates (Hydrogen Carbonate)IBA 01/2022
1	allogenic effect factor (AEF)IBA 10/2021
1	CatecholaminesIBA 10/2021
1	Thiamine (Aneurin)FDA Link 01/2021
1	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2021
1	ethyl 2- (5- (4- chlorophenyl)pentyl)oxiran- 2- carboxylate (POCA)IBA 01/2021
1	Lipopolysaccharide ReceptorsIBA 01/2021
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2021

Therapy/Procedure

23	Therapeutics 01/2022 - 07/2004
8	Drug Therapy (Chemotherapy) 01/2021 - 12/2006
3	Combination Drug Therapy (Combination Chemotherapy) 04/2014 - 02/2004
2	Resuscitation 12/2021 - 04/2020
1	Continuous Renal Replacement Therapy 01/2022
1	Critical Care (Surgical Intensive Care) 01/2022
1	Airway Management 12/2021
1	Advanced Cardiac Life Support (Life Support, Advanced Cardiac) 12/2021
1	Emergency Treatment 10/2021